For those who require treatment, the current first-line bisphosphonate, due to its potency and prolonged duration of action, is zoledronate (zoledronic acid). It is the bisphosphonate most likely to relieve pain from active Paget’s disease. It is usually given in a hospital, as an outpatient.
A single dose of 5mg is given through an infusion (a drip) directly into the bloodstream (intravenous), over 15 to 30 minutes.
Over the following months, this treatment often normalises the abnormal bone remodelling and one dose can be effective for many years.
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