Mr Michael Cook and Professor Terence O’Neill, from the University of Manchester, discuss below research published in April 2021, which looks at the occurrence of Paget’s disease in the UK. Professor O’Neill is the director of the Paget’s Association’s Centre of Excellence in Salford.
The PRISM study (Paget’s disease, Randomised trial of Intensive versus Symptomatic Management) was carried out by an Edinburgh research team, supported by a research grant from the Association. This looked at newly identified genes to see if it would be possible to predict the severity, complications or response to treatment in people with Paget’s disease.
What goes wrong inside bone cells in Paget’s disease?
Dr Rob Layfield is a biochemist based at the University of Nottingham, who has researched Paget’s disease since 2002. Here he gives an overview of his work and an insight into the valuable role that organisations such as the Paget’s Association play in supporting research.
Bone cancer associated with Paget’s Disease of Bone
Dr Darrell Green, from Norwich, was the recipient of the Allan Reid Student Research Bursary to pursue exciting research into a rare bone cancer (osteosarcoma) associated with Paget’s Disease of Bone.
Scientists Solve an 800-year-old Mystery Related to Paget’s Disease
Funding from the Paget’s Association has helped scientists solve an 800-year-old mystery related to Paget’s Disease of Bone. Scientific research at the molecular level, on a collection of medieval skeletons from Norton Priory in Cheshire, could help rewrite history after revealing they were affected by an unusual ancient form of the disorder.
(Scroll down to watch a video about this research)
